2-methyl-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-2-ol → HCID 89995585, compound

HRID 523072Notes

Reaction equation

HRID 523072 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](Cl)=[N:9]2)=[CH:4][N:3]=1.[CH3:13][C:14]([OH:31])([CH3:30])[CH2:15][N:16]1[CH:20]=[C:19](B2OC(C)(C)C(C)(C)O2)[CH:18]=[N:17]1>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([C:19]3[CH:18]=[N:17][N:16]([CH2:15][C:14]([CH3:30])([OH:31])[CH3:13])[CH:20]=3)=[N:9]2)=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 582041312-methyl-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-2-olHCID 899956037-Bromo-2-chloro-1,6-naphthyridine

Product 1

HCID 89995585HCID 89995585, compound

Procedure

The title compound was prepared according to the method described for Preparation 58 using 7-Bromo-2-chloro-1,6-naphthyridine (Preparation 61) and 2-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propan-2-ol (Preparation 124).

Sources & evidence

ORD record
ord-0278e3d8f21b444eb1fdae3a2840c514
Source dataset
uspto-grants-2016_05
Patent number
US09334286B2

Reaction notes

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