7-Bromo-2-chloro-1,6-naphthyridine → HCID 89995731, compound

HRID 523073Notes

Reaction equation

HRID 523073 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](Cl)=[N:9]2)=[CH:4][N:3]=1.CC1(C)C(C)(C)OB([C:21]2[CH:22]=[N:23][N:24]([CH2:26][C:27]3([OH:31])[CH2:30][CH2:29][CH2:28]3)[CH:25]=2)O1>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([C:21]3[CH:22]=[N:23][N:24]([CH2:26][C:27]4([OH:31])[CH2:30][CH2:29][CH2:28]4)[CH:25]=3)=[N:9]2)=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 899956037-Bromo-2-chloro-1,6-naphthyridineHCID 90000653HCID 90000653, compound

Product 1

HCID 89995731HCID 89995731, compound

Procedure

The title compound was prepared according to the method described for Preparation 58 using 7-Bromo-2-chloro-1,6-naphthyridine (Preparation 61) and 1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)cyclobutanol (Preparation 131).

Sources & evidence

ORD record
ord-e12d9a23e9fc4506806bc627c49293b7
Source dataset
uspto-grants-2016_05
Patent number
US09334286B2

Reaction notes

Loading…