反应详情

A solution of 4-(3-chloro-4-nitrophenyl)morpholine (Preparation 112, 450 mg, 1.854 mmol) in EtOH/EtOAc (1:1, 30 mL) was passed through a 10% Pd/C cartridge using an H-cube (atmospheric H2, room temperature, 1 mL/min). The reaction mixture was concentrated in vacuo. The residue was purified by reverse phase column chromatography eluting with 0-20% MeCN in water to afford the title compound (150 mg, 38%).

1. customan H-cube (atmospheric H2, room temperature, 1 mL/min)
2. concentrationThe reaction mixture was concentrated in vacuo
3. customThe residue was purified by reverse phase column chromatography
4. washeluting with 0-20% MeCN in water