HCID 59549040, compound → HCID 68508220, compound

HRID 523314Notes

Reaction equation

HRID 523314 reaction equation
C1(C2C3C=CC4C(=O)NCCC=CCCNC(=O)CN(C=3C=4)C=2C2C=CC(OCC3C=C([N+]([O-])=O)C=CC=3N3CCN(S(C)(=O)=O)CC3)=CC=2)CCCCC1.[CH2:56]([NH:60][C:61]([C:63]1[CH:71]=[C:70]2[C:66]([C:67]([CH:106]3[CH2:111][CH2:110][CH2:109][CH2:108][CH2:107]3)=[C:68]([C:80]3[CH:85]=[CH:84][C:83]([O:86][CH2:87][C:88]4[CH:93]=[C:92]([N:94]5[CH2:98][CH2:97][CH2:96][C:95]5=[O:99])[CH:91]=[CH:90][C:89]=4[N:100]4[CH2:105][CH2:104][O:103][CH2:102][CH2:101]4)=[CH:82][CH:81]=3)[N:69]2[CH2:72][C:73](=[O:79])[NH:74][CH2:75][CH2:76][CH:77]=[CH2:78])=[CH:65][CH:64]=1)=[O:62])[CH2:57]C=C>>[CH:106]1([C:67]2[C:66]3[CH:65]=[CH:64][C:63]4[C:61](=[O:62])[NH:60][CH2:56][CH2:57][CH:78]=[CH:77][CH2:76][CH2:75][NH:74][C:73](=[O:79])[CH2:72][N:69]([C:70]=3[CH:71]=4)[C:68]=2[C:80]2[CH:85]=[CH:84][C:83]([O:86][CH2:87][C:88]3[CH:93]=[C:92]([N:94]4[CH2:98][CH2:97][CH2:96][C:95]4=[O:99])[CH:91]=[CH:90][C:89]=3[N:100]3[CH2:105][CH2:104][O:103][CH2:102][CH2:101]3)=[CH:82][CH:81]=2)[CH2:107][CH2:108][CH2:109][CH2:110][CH2:111]1

Participants

3

Reactant 2

HCID 59549040HCID 59549040, compoundHCID 74928751HCID 74928751, compound

Product 1

HCID 68508220HCID 68508220, compoundYield 25%

Procedure

The target product 17-cyclohexyl-18-[4-[2-morpholin-4-yl-5-(2-oxo-pyrrolidin-1-yl)-benzyloxy]-phenyl]-1,4,11-triaza-tricyclo[11.5.2.016,19]icosa-7,13 (20),14,16(19),17-pentaene-3,12-dione 11 was synthesized in 25% yield, following the procedure reported for the synthesis of compound 3 and using intermediate 10-11 instead of intermediate 3-11; m/z=730 (M+H)+.

Sources & evidence

ORD record
ord-d6f7ccfd38784a0180687e63afd9426e
Source dataset
uspto-grants-2016_05
Patent number
US09334282B2

Reaction notes

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