HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyrimidine-5-boronic acid, pinacol ester → Apitolisib
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyrimidine-5-boronic acid, pinacol ester | HCID 17750212 | — |
| Reactant | (S)-1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one | HCID 86623526 | — |
| Product | Apitolisib | HCID 25254071 | — |
Reaction Steps
(S)-1-(4-((2-Chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one (60 mg) was reacted with 50 mg of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine via General Procedure A-2 to give 10 mg of Formula Ib (US 2008/0242665, incorporated by reference). MS (Q1) 499.3 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09335320B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-e99fdd1ac1d64a40af369ba65ffbb154 |
| Source note | uspto-grants-2016_05 |