反应详情

19.6 g (100 mmol) of benzo[c]-2,6-napthyridinone, 106 g (300 mmol) of 5′-iodo-[1,1′;3′,1″]terphenyl and 2.3 g (20 mmol) of L-proline are stirred at 150° C. in 100 ml for 30 h The solution is diluted with water, extracted twice with ethyl acetate, the combined organic phases are dried over Na2SO4 and evaporated in a rotary evaporator. The residue is purified by chromatography (EtOAc/hexane: 2/3). The yield is 25 g (59 mmol) 60% of theory.

1. extractionextracted twice with ethyl acetate
2. dry with materialthe combined organic phases are dried over Na2SO4
3. customevaporated in a rotary evaporator
4. customThe residue is purified by chromatography (EtOAc/hexane: 2/3)