反应详情

5-chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid 11-b (25.20 g, 128.18 mmol) was added to a refluxing mixture of sulfuric acid (20 ml) and methanol (400 ml). The mixture was refluxed overnight. The mixture was then evaporated and a cold NaHCO3 solution was added until basic pH. The precipitate was filtered off and dried, yielding 16.15 g of the desired product (59.8%). m/z=211.17 (M+H)+, Cl pattern.

1. temperatureThe mixture was refluxed overnight
2. customThe mixture was then evaporated
3. additiona cold NaHCO3 solution was added until basic pH
4. filtrationThe precipitate was filtered off
5. customdried