HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-[4-(3-Methoxyphenyl)piperazinyl]-3,5,6,7,8-pentahydroquinazolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-(3-Methoxyphenyl)piperazine hydrochloride | HCID 12645572 | — |
| Reactant | 2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one | HCID 135435256 | — |
| Solvent | Isoamyl Alcohol | HCID 31260 | — |
| Product | 2-[4-(3-Methoxyphenyl)piperazinyl]-3,5,6,7,8-pentahydroquinazolin-4-one | HCID 135644892 | — |
Reaction Steps
2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol), 1-(3-methoxyphenyl)piperazine hydrochloride (116.5 mg; 0.51 mmol) and triethylamine (141.3 μl; 1.02 mmol) are reacted in isoamyl alcohol (1 ml) in accordance with the procedure for Example 1 (reaction time 4 h) and worked up; yield: 79 mg (45%), crystals;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09339503B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-1856f6ca246740aebd396f89b07389de |
| Source note | uspto-grants-2016_05 |