1-Tert-butylpiperazine → HCID 136268340, compound

HRID 523485Notes

Reaction equation

HRID 523485 reaction equation
CS[C:3]1[NH:12][C:11](=[O:13])[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=1.[C:14]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)([CH3:17])([CH3:16])[CH3:15]>C(O)CC(C)C>[C:14]([N:18]1[CH2:23][CH2:22][N:21]([C:3]2[NH:12][C:11](=[O:13])[C:10]3[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=3[N:4]=2)[CH2:20][CH2:19]1)([CH3:17])([CH3:16])[CH3:15]

Participants

4

Reactant 2

HCID 35305721-Tert-butylpiperazineHCID 1354352562-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one

Product 1

HCID 136268340HCID 136268340, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol) and 1-tert-butylpiperazine (72.5 mg; 0.51 mmol) are reacted in isoamyl alcohol (1 ml) in accordance with the procedure for Example 1 and worked up; yield: 42 mg (28%), crystals.

Sources & evidence

ORD record
ord-09e46cfd23f144cda0da8803746483a8
Source dataset
uspto-grants-2016_05
Patent number
US09339503B2

Reaction notes

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