1-Acetylpiperazine → HCID 135611929, compound

HRID 523490Notes

Reaction equation

HRID 523490 reaction equation
CS[C:3]1[NH:12][C:11](=[O:13])[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=1.[C:14]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)(=[O:16])[CH3:15]>C(O)CC(C)C>[C:14]([N:17]1[CH2:22][CH2:21][N:20]([C:3]2[NH:12][C:11](=[O:13])[C:10]3[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=3[N:4]=2)[CH2:19][CH2:18]1)(=[O:16])[CH3:15]

Participants

4

Reactant 2

HCID 837951-AcetylpiperazineHCID 1354352562-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one

Product 1

HCID 135611929HCID 135611929, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol) and N-acetylpiperazine (98 mg; 0.76 mmol) are reacted in isoamyl alcohol (1 ml) in accordance with the procedure for Example 1 (reaction time 8 h) and worked up. The crude product obtained in this way is purified by column chromatography; yield: 12 mg (8%), crystals;

Sources & evidence

ORD record
ord-05d2613c182e41a5a0be377390fe1a8b
Source dataset
uspto-grants-2016_05
Patent number
US09339503B2

Reaction notes

Loading…