1-(4-Methoxyphenyl)-2-piperazinone → HCID 136268341, compound

HRID 523494Notes

Reaction equation

HRID 523494 reaction equation
CS[C:3]1[NH:12][C:11](=[O:13])[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[N:4]=1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][C:23]2=[O:28])=[CH:18][CH:17]=1>C(O)CC(C)C>[CH3:14][O:15][C:16]1[CH:17]=[CH:18][C:19]([N:22]2[CH2:27][CH2:26][N:25]([C:3]3[NH:12][C:11](=[O:13])[C:10]4[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=4[N:4]=3)[CH2:24][C:23]2=[O:28])=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 154000201-(4-Methoxyphenyl)-2-piperazinoneHCID 1354352562-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one

Product 1

HCID 136268341HCID 136268341, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

2-Methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one (100 mg; 0.51 mmol) and 1-(4-methoxyphenyl)piperazin-2-one (105 mg; 0.51 mmol) are reacted in isoamyl alcohol (1 ml) in accordance with the procedure for Example 1 (reaction time 4 h) and worked up. The crude product obtained in this way is purified by column chromatography; yield: 8 mg (4%), crystals; HPLC method P; RT/min 2,87.

Sources & evidence

ORD record
ord-c11ebba4f76447b389d8d3a6edec1b84
Source dataset
uspto-grants-2016_05
Patent number
US09339503B2

Reaction notes

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