Potassium Phosphate, Tribasic → HCID 66576489, compound

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 100 mg, 0.492 mmol) was reacted with 4-bromo-2-methoxypyridine (111.1 mg, 0.591 mmol), 1,4-dioxane (5 mL), copper iodide (9.39 mg, 0.049 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (6.98 mg, 0.049 mmol) and potassium phosphate (312.9 mg, 1.476 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in CHCl3) afforded 80 mg of the product (52% yield).

Provenance & Evidence