Potassium Phosphate, Tribasic → HCID 66576563, compound

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 120 mg, 0.591 mmol) was reacted with 4,6-dichloropyrimidine (88.07 mg, 0.591 mmol), 1,4-dioxane (5 mL), copper iodide (11.21 mg, 0.059 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (8.39 mg, 0.059 mmol) and potassium phosphate (375.96 mg, 1.77 mmol) to afford the crude product. Purification by column chromatography on silica gel (0.5% methanol in CHCl3) afforded 15.3 mg of the product (9% yield).

Provenance & Evidence