Potassium Phosphate, Tribasic → 1-(4-Cyclopropylpyridin-3-yl)-3-(2-(trifluoromethyl) pyrimidin-4-yl)imidazolidin-2-one

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 100 mg, 0.492 mmol) was reacted with 4-chloro-2-(trifluoromethyl)pyrimidine (108 mg, 0.591 mmol), 1,4-dioxane (5 mL), copper iodide (9.3 mg, 0.049 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (6.9 mg, 0.049 mmol) and potassium phosphate (313 mg, 1.47 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in CHCl3), followed by preparative HPLC afforded 20 mg of the product (12% yield).

Provenance & Evidence