Potassium Phosphate, Tribasic → 1-(4-Cyclopropylpyridin-3-yl)-3-(3-methylbenzofuran-5-yl)imidazolidin-2-one

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 100 mg, 0.492 mmol) was reacted with 5-bromo-3-methylbenzofuran (125 mg, 0.5904 mmol), 1,4-dioxane (4 mL), copper iodide (10 mg, 0.0492 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (7.0 mg, 0.0492 mmol) and potassium phosphate (313 mg, 1.476 mmol) to afford the crude product. Purification by column chromatography on silica gel (1.0% methanol in CHCl3) afforded 69 mg of the product (42% yield).

Provenance & Evidence