Potassium Phosphate, Tribasic → HCID 66576648, compound

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 100 mg, 0.491 mmol) was reacted with 5-bromo-2-chloro-benzo[b]thiophene- (134.6 mg, 0.541 mmol), copper iodide (9.3 mg, 0.049 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (7.0 mg, 0.0491 mmol), potassium phosphate (260.9 mg, 1.23 mmol) and 1,4-dioxane (5 mL to yield the crude product. Purification by column chromatography on silica gel (1.5% methanol in DCM), afforded 60.0 mg of the product (33% yield)

Provenance & Evidence