Potassium Phosphate, Tribasic → HCID 66576650, compound

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 100 mg, 0.4926 mmol) was reacted with 2-bromo-5-fluorobenzo[b]thiophene (125 mg, 0.5418 mmol), 1,4-dioxane (4 mL), copper iodide (9.3 mg, 0.0492 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (7.0 mg, 0.0492 mmol) and potassium phosphate (261 mg, 1.231 mmol) to afford the crude product. Purification by column chromatography on silica gel (0.5% methanol in CHCl3) afforded 85 mg of the product (49% yield).

Provenance & Evidence