Potassium Phosphate, Tribasic → HCID 66576651, compound

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 170 mg, 0.837 mmol) was reacted with 6-bromo-3-(trifluoromethyl)benzo[b]thiophene (259 mg, 0.921 mmol), 1,4-dioxane (8 mL), copper iodide (15.9 mg, 0.083 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (11.9 mg, 0.083 mmol) and potassium phosphate (533 mg, 2.51 mmol) to afford the crude product. Purification by column chromatography on silica gel (0.4% methanol in CHCl3) afforded 15 mg of the product (4% yield).

Provenance & Evidence