Potassium Phosphate, Tribasic → HCID 66576729, compound

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 150 mg, 0.738 mmol) was reacted with 6-Bromo-2-fluoro-benzo[b]thiophene (I-25d: 170.6 mg, 0.738 mmol), copper iodide (14.2, 0.071 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (10.2 mg, 0.071 mmol), potassium phosphate (469.9 mg, 2.21 mmol) and 1,4-dioxane (5 mL) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in CHCl3), followed by preparative HPLC afforded 11.6 mg of the product (4% yield).

Provenance & Evidence