Potassium Phosphate, Tribasic → HCID 66576730, compound

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 120 mg, 0.591 mmol) was reacted with 6-bromo-4-fluoro-benzo[b]thiophene (I-26d: 163.6 mg, 0.738 mmol), copper iodide (11.2 mg, 0.059 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (8.9 mg, 0.0591 mmol), potassium phosphate (375.9 mg, 1.7 mmol) and 1,4-dioxane (5 mL). Purification by column chromatography on silica gel (0.3% methanol in CHCl3) afforded 51.2 mg of the product (26% yield).

Provenance & Evidence