Potassium Phosphate, Tribasic → 1-(4-Cyclopropyl-pyridin-3-yl)-3-(5-fluoro-benzo[b]thiophen-6-yl)-imidazolidin-2-one

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 100 mg, 0.491 mmol) was reacted with 6-bromo-5-fluoro-benzo[b]thiophene (I-27d: 136 mg, 0.5901 mmol), copper iodide (28 mg, 0.147 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (21 mg, 0.147 mmol), potassium phosphate (313.9 mg, 1.7 mmol) and 1,4-dioxane (5 mL) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in CHCl3) afforded 80 mg of the product (46% yield).

Provenance & Evidence