HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-Bromo-6-fluorobenzo[b]thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 5-bromo-6-fluorobenzo[b]thiophene-2-carboxylate | HCID 70983611 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Bromo-6-fluorobenzo[b]thiophene-2-carboxylic acid | HCID 70983054 | 85% |
Reaction Steps
Using analogous reagents and reaction conditions as described in Example 25 for the preparation of I-25b above, methyl 5-bromo-6-fluorobenzo[b]thiophene-2-carboxylate (I-28b: 0.3 g, 1.038 mmol) in THF (10 mL) was hydrolyzed with LiOH (300 mg, 1.038 mmol) and water (2 mL) to afford 240 mg of the product (85% yield)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09339501B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-1927cd95e5e24d179c86209822941e08 |
| Source note | uspto-grants-2016_05 |