Cesium carbonate → HCID 66576563, compound

Participants

Reaction Steps

Using analogous reagents and reaction conditions as described in Example 11 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 500 mg, 2.46 mmol) was reacted with 4,6-dichloro-pyrimidine (403 mg, 2.70 mmol), 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (117 mg, 0.246 mmol), Pd2(dba)3 (112 mg, 0.123 mmol), cesium carbonate (2.009 g, 6.15 mmol) and toluene (10 mL) in seal tube at 110° C. for 14 hours. Purification by column chromatography on silica gel (1.5% methanol in chloroform) afforded 140 mg of the product (18.18% yield).

Provenance & Evidence