HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Chloro-4-hydroxy-6-isopropoxy-isoquinoline-3-carboxylic acid → (R)-2-[(1-Chloro-4-hydroxy-6-isopropoxy-isoquinoline-3-carbonyl)-amino]-3-hydroxy-propionic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Chloro-4-hydroxy-6-isopropoxy-isoquinoline-3-carboxylic acid | HCID 54242250 | — |
| Edukt | H-D-Ser(tBu)-OtBu.HCl | HCID 56777372 | — |
| Produkt | (R)-2-[(1-Chloro-4-hydroxy-6-isopropoxy-isoquinoline-3-carbonyl)-amino]-3-hydroxy-propionic acid | HCID 86595450 | — |
Reaktionsschritte
Prepared in analogy to Example A-2 e) and f) from 1-chloro-4-hydroxy-6-isopropoxy-isoquinoline-3-carboxylic acid (can be obtained according to U.S. Pat. No. 6,093,730, October 1998, Weidmann et al.) and (R)-2-amino-3-tert-butoxy-propionic acid tert-butyl ester hydrochloride; MS-(+)-ion: M+1=369.0 amu.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09339527B2 |
| Quelldatensatz | uspto-grants-2016_05 |
| ORD ID | ord-746ff8ab61e04e43a03dfbf84067f1bd |
| Quellennotiz | uspto-grants-2016_05 |