L-Alanine → HCID 57423246, compound

HRID 523671Notes

Reaction equation

HRID 523671 reaction equation
C(O[C:6]([C:8]1[N:9]=[CH:10][C:11]2[C:16]([C:17]=1[OH:18])=[CH:15][CH:14]=[C:13]([O:19][C:20]1[CH:25]=[CH:24][C:23]([F:26])=[C:22]([F:27])[CH:21]=1)[CH:12]=2)=[O:7])CCC.[NH2:28][C@H:29]([C:31]([OH:33])=[O:32])[CH3:30]>>[F:27][C:22]1[CH:21]=[C:20]([CH:25]=[CH:24][C:23]=1[F:26])[O:19][C:13]1[CH:12]=[C:11]2[C:16]([C:17]([OH:18])=[C:8]([C:6]([NH:28][CH:29]([CH3:30])[C:31]([OH:33])=[O:32])=[O:7])[N:9]=[CH:10]2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 5950L-AlanineHCID 66712799HCID 66712799, compound

Product 1

HCID 57423246HCID 57423246, compound

Procedure

Prepared in analogy to Example A-50 by reacting 7-(3,4-Difluoro-phenoxy)-4-hydroxy-isoquinoline-3-carboxylic acid butyl ester (compound of Example A-62 a) with L-alanine in a pressure tube for 3 days at 85° C. MS-(+)-ion: M−1=389.2.

Workup

  1. customfor 3 days
  2. customat 85° C

Sources & evidence

ORD record
ord-a5a709bc00524b2d866be1c93e57b748
Source dataset
uspto-grants-2016_05
Patent number
US09339527B2

Reaction notes

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