HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 523690Generated: October 27, 2026
p-Chlorothiophenol → (S)-2-{[1-(4-Chloro-phenylsulfanyl)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-propionic acid
https://huagongshe.com/reaction/523690
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Chlorothiophenol | HCID 7815 | — |
| Reactant | (S)-2-{[1-bromo-4-hydroxy-isoquinoline-3-carbonyl]-amino}-propionic acid | HCID 86595466 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | (S)-2-{[1-(4-Chloro-phenylsulfanyl)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-propionic acid | HCID 66713177 | 6.1% |
Reaction Steps
To a solution of 250 mg of (S)-2-{[1-bromo-4-hydroxy-isoquinoline-3-carbonyl]-amino}-propionic acid in 0.7 ml of 1-methyl-2-pyrrolidinone was added 433 mg of 4-chlorobenzenethiol. The solution was heated at 210° C. for 30 min. using a CEM Discover microwave reactor. The solution was concentrated under vacuum. The resultant residue was crystallized from methanol to yield 18 mg of a tan solid; MS (−): m/z 401.10 (M−1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09339527B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-e7297b59a64d4301a23a4d16e502c323 |
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| Source note | uspto-grants-2016_05 |
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