HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxyphthalic acid → (5-Hydroxy-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxyphthalic acid | HCID 11881 | — |
| Reactant | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| Product | (5-Hydroxy-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid ethyl ester | HCID 66712563 | — |
Reaction Steps
Prepared in analogy to example D-100 c) from 4-hydroxy-phthalic acid and glycine ethyl ester HCl salt. 1H NMR (200 MHz, DMSO-d6) δ 11.0 (br s, 1H), 7.74 (d, J=7.8 Hz, 1H), 7.17 (m, 2H), 4.35 (s, 2H), 4.13 (q, J=7.0 Hz, 2H), 1.20 (t, J=7.0 Hz, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09339527B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-381c070e28ab47489b824fe00b21c06a |
| Source note | uspto-grants-2016_05 |