HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycine → Glycine, N-[[4-hydroxy-6-(phenylthio)-3-isoquinolinyl]carbonyl]-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycine | HCID 750 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 66712774 | HCID 66712774 | — |
| Product | Glycine, N-[[4-hydroxy-6-(phenylthio)-3-isoquinolinyl]carbonyl]- | HCID 11175664 | — |
Reaction Steps
127 mg of 4-hydroxy-6-phenylsulfanyl-isoquinoline-3-carboxylic acid butyl ester (0.36 mmol) were reacted with glycine and sodium methylate analogously to Example D-1 g). 118 mg of the title compound were obtained; 1H NMR (DMSO-d6): δ=9.33 (t, 1H), 8.80 (s, 1H), 8.11 (d, 1H), 7.79 (s, 1H), 7.49 to 7.65 (m, 6H), 4.01 (d, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09339527B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-fca4d65bd6f94e27994678c0cf588f6d |
| Source note | uspto-grants-2016_05 |