Glycine → HCID 66712759, compound

HRID 523747Notes

Reaction equation

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([C:12]([OH:14])=O)[C:6](=[CH:10][CH:11]=1)[C:7]([OH:9])=O.[NH2:17][CH2:18][C:19]([OH:21])=[O:20].[CH3:22]O>>[CH3:22][O:20][C:19](=[O:21])[CH2:18][N:17]1[C:12](=[O:14])[C:5]2[C:6](=[CH:10][CH:11]=[C:3]([C:2]([F:1])([F:16])[F:15])[CH:4]=2)[C:7]1=[O:9]

Participants

Reactant 3

HCID 750Glycine

HCID 887Methanol

HCID 5990394-(Trifluoromethyl)phthalic acid

Product 1

HCID 66712759HCID 66712759, compound

Procedure

4-trifluoromethyl-phthalic acid was reacted with glycine in analogy to Example D-1 b). The crude product was then reacted with methanol in analogy to Example D-1 c); 1H NMR (CDCl3): δ=8.14 (s, 1H), 8.02 (m, 2H), 4.48 (s, 2H), 3.78 (s, 3H).

Sources & evidence

ORD record: ord-33c84715d814414c8add2473d5825c73
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09339527B2

Reaction notes

Loading…