HCID 71449121, compound → HCID 66712672, compound

HRID 523846Notes

Reaction equation

HRID 523846 reaction equation
[CH:1]1C=CC(C([C@H]2OCC(NCCC3C=CC(F)=CC=3)C(O)C2)C2C=CC=CC=2)=CC=1.[CH2:31]([O:35][C:36]([C:38]1[N:39]=[C:40](Cl)[C:41]2[C:46]([C:47]=1[OH:48])=[CH:45][CH:44]=[C:43]([O:49][C:50]1[CH:55]=[CH:54][C:53]([C:56]([F:59])([F:58])[F:57])=[CH:52][CH:51]=1)[CH:42]=2)=[O:37])[CH2:32][CH2:33][CH3:34]>>[CH2:31]([O:35][C:36]([C:38]1[N:39]=[C:40]([CH3:1])[C:41]2[C:46]([C:47]=1[OH:48])=[CH:45][CH:44]=[C:43]([O:49][C:50]1[CH:55]=[CH:54][C:53]([C:56]([F:59])([F:58])[F:57])=[CH:52][CH:51]=1)[CH:42]=2)=[O:37])[CH2:32][CH2:33][CH3:34]

Participants

3

Reactant 2

HCID 71449121HCID 71449121, compoundHCID 86595483HCID 86595483, compound

Product 1

HCID 66712672HCID 66712672, compound

Procedure

Prepared in analogy to Example D-157 d) from 4-hydroxy-1-chloro-7-(4-trifluoromethyl-phenoxy)-isoquinoline-3-carboxylic acid butyl ester (of Example D-92 f). MS-(+)-ion M+1=420.2.

Sources & evidence

ORD record
ord-dbd63d8b4ce54b71a9d01af73068b963
Source dataset
uspto-grants-2016_05
Patent number
US09339527B2

Reaction notes

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