Pridinol → (S)-(+)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine

HRID 523861Notes

Reaction equation

[CH3:1][N:2]([CH2:4][CH2:5]C1C=CC=CC=1)C.[C:12]1([C:18]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)([OH:27])[CH2:19][CH2:20]N2CCCCC2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH3:1][N:2]1[CH2:4][CH2:5][CH2:20][C@H:19]1[C:18]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[OH:27]

Participants

Reactant 2

HCID 4904Pridinol

HCID 25125N,N-Dimethylphenylethylamine

Product 1

HCID 853009(S)-(+)-2-[Hydroxy(diphenyl)methyl]-1-methylpyrrolidine

Procedure

LC-MS (ESI) m/z (%): 268 (0) [M0+H]+, 269 (4), 270 (13), 271 (22), 272 (22), 273 (16), 274 (14), 275 (7), 276 (1).

Sources & evidence

ORD record: ord-f1ae8251c0124ba498b446058a10eae8
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340489B2

Reaction notes

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