Iodoethane → HCID 86660146, compound

Participants

Reaction Conditions

Reaction Steps

K2CO3 (21 mg, 0.15 mmol) was added to II (31 mg, 0.10 mmol) in DMF (2 mL) at it under Ar(g). After 15 min iodoethane (9 μL, 0.11 mmol) was added and the reaction was stirred at 70° C. for 26 h. Brine (50 mL) and EtOAc (25 mL) were added, then the phases were separated, and the aqueous phase was extracted with EtOAc (25 mL). The organic phases were combined then dried over MgSO4, filtered, and subsequently evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography eluting with hexane/EtOAc (60:40) to furnish III as a colourless oil (16 mg, 43%).

Provenance & Evidence