HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 5-Bromo-6-cyclopropylmethoxy-1,2,3,4-tetrahydro-isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-(2-Bromo-3-cyclopropylmethoxy-phenyl)-ethylamine | HCID 84061381 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromo-6-cyclopropylmethoxy-1,2,3,4-tetrahydro-isoquinoline | HCID 118939125 | — |
Reaction Steps
To 40 mg (0.15 mmol) 2-(2-bromo-3-cyclopropylmethoxy-phenyl)-ethylamine (example XXI) and 17 μL (0.22 mmol) formaldehyde (37% solution in water) in 2 mL DCM are added slowly 23 μL (0.30 mmol) TFA and the resulting mixture is stirred at r.t. over night. The reaction mixture is concentrated by evaporation
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340510B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-928b837a2b4d4ca28d22779747387bb1 |
| Source note | uspto-grants-2016_05 |