Acetic Anhydride → HCID 84666158, compound

HRID 524000Notes

Reaction equation

HRID 524000 reaction equation
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:10][CH2:11][NH2:12].[C:13](OC(=O)C)(=O)[CH3:14]>C(Cl)Cl>[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[C:4]2[C:3]=1[CH2:10][CH2:11][NH:12][CH:13]2[CH3:14]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 53493300HCID 53493300, compound

Product 1

HCID 84666158HCID 84666158, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 500 mg (2.96 mmol) 2-(2-fluoro-3-methoxy-phenyl)-ethylamine and 622 μL (3.10 mmol) TEA in 7 mL DCM are added slowly 293 μL (3.83 mmol) acetic anhydride at 0° C. and stirring is continued for 2 h. After that time, the reaction mixture is quenched by the addition of water and extracted three times with DCM. The organic layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo.

Workup

  1. customAfter that time, the reaction mixture is quenched by the addition of water
  2. extractionextracted three times with DCM
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-14b1db93e7db460288d1a275e7c85945
Source dataset
uspto-grants-2016_05
Patent number
US09340510B2

Reaction notes

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