Sodium Hydroxide → HCID 118939113, compound

Participants

Reaction Conditions

Reaction Steps

To 560 mg (1.53 mmol) 2-[4-((S)-1-acetylamino-ethyl)-benzyl]-1,2,3,4-tetrahydro-isoquinoline-5-carboxylic acid methyl ester (example XXXVI) in 5 mL MeOH are added 1.68 mL (1.68 mmol) aq. NaOH solution (c=1 mol/L). The reaction mixture is stirred for 1 h at 70° C. After that time, the solvent is partially removed in vacuo and the residue is extracted with DCM. The aq. layer is separated, alkalized with aq. HCl solution (c=1 mol/L) and extracted with EtOAc. The aq. layer was separated and the solvent was removed by lyophilization.

Provenance & Evidence