Formaldehyde → HCID 118939074, compound

Participants

Reaction Steps

To 10 g (41 mmol) 2-amino-1-[3-(benzyloxy)phenyl]ethan-1-ol and 4.6 mL (62 mmol) formaldehyde (37% solution in water) in 100 mL DCM are added slowly 6.3 mL (82 mmol) TFA and the resulting mixture is stirred at r.t. over night. The reaction is neutralised by the addition of a sat. aq. NaHCO3 solution and extracted with DCM. The organic layer is washed with a sat. aq. NaCl solution, dried over MgSO4, filtered and the solvent is removed in vacuo.

Provenance & Evidence