Cyanoacetic acid → HCID 118939087, compound

Participants

Reaction Steps

1.70 mg (20.0 μmol) Cyanoacetic acid, 4.09 mg (10.0 μmol) (S)-1-{4-[6-(2,2-difluoro-cyclopropylmethoxy)-3,4-dihydro-1H-isoquinolin-2-ylmethyl]-phenyl}-ethylamine hydrochloride (example XXXIII.1) and 6.88 μL (40.0 μmol) DIPEA in 0.5 mL ACN are stirred at r.t. Then 4.18 mg (15.0 μmol) CIP are added and the resulting mixture is stirred at r.t. over night. The reaction is quenched by the addition of 25 μL aq. K2CO3 solution (c=3 mol/L), filtered over basic aluminum oxide and concentrated by evaporation.

Provenance & Evidence