反应详情

15 mg (39 μmol) 2-[4-((S)-1-Acetylamino-ethyl)-benzyl]-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid methyl ester (example XXXVIII), 5.8 mg (43 μmol) (bromomethyl)cyclopropane and 10 mg (78 μmol) K2CO3 in 2 mL DMF are stirred at 80° C. over night. The reaction mixture is diluted with water and extracted with DCM. The organic layer is concentrated by evaporation and the residue is purified by HPLC.

1. extractionextracted with DCM
2. concentrationThe organic layer is concentrated by evaporation
3. customthe residue is purified by HPLC