反应详情

A mixture of 10 g 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1), 8 g of 3-(acetyloxy)benzoic acid and 7 g of DCC in 150 ml of DCM is stirred for 2 h until the reaction is complete according to TLC analysis. The reaction mixture is quenched with water, the phases are separated and the organic phase is washed with water again. The organic phase is dried over MgSO4, and the solvent is removed under reduced pressure resulting in a crude product, which is purified by crystallization from methanol to yield the title compound.

1. customThe reaction mixture is quenched with water
2. customthe phases are separated
3. washthe organic phase is washed with water again
4. dry with materialThe organic phase is dried over MgSO4
5. customthe solvent is removed under reduced pressure
6. customresulting in a crude product, which
7. customis purified by crystallization from methanol