1,3-Benzenedicarboxylic acid, 5-(chlorosulfonyl)-, 1,3-dimethyl ester → HCID 86657434, compound

HRID 524157Notes

Reaction equation

HRID 524157 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].Cl[S:27]([C:30]1[CH:31]=[C:32]([C:40]([O:42][CH3:43])=[O:41])[CH:33]=[C:34]([CH:39]=1)[C:35]([O:37][CH3:38])=[O:36])(=[O:29])=[O:28]>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][N:20]([S:27]([C:30]4[CH:39]=[C:34]([C:35]([O:37][CH3:38])=[O:36])[CH:33]=[C:32]([CH:31]=4)[C:40]([O:42][CH3:43])=[O:41])(=[O:29])=[O:28])[CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 37891971,3-Benzenedicarboxylic acid, 5-(chlorosulfonyl)-, 1,3-dimethyl esterHCID 666164065-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride2×

Product 1

HCID 86657434HCID 86657434, compound

Procedure

The title compound is prepared analogously as described for GP1 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and dimethyl 5-(chlorosulfonyl)isophthalate as starting compounds. The crude product is purified by crystallization from EA and diethyl ether to yield the title compound.

Workup

  1. customThe title compound is prepared analogously
  2. customThe crude product is purified by crystallization from EA and diethyl ether

Sources & evidence

ORD record
ord-fda0c5ad175547bd9339c1348cd0ee2e
Source dataset
uspto-grants-2016_05
Patent number
US09340522B2

Reaction notes

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