Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 524174Generated: October 30, 2026

1,8-Naphthyridine-2-carboxylic acid → HCID 46204342, compound

https://huagongshe.com/reaction/524174

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,8-Naphthyridine-2-carboxylic acidHCID 735156—
Reactant5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochlorideHCID 66616406—
ProductHCID 46204342HCID 46204342—

Reaction Steps

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 1,8-naphthyridine-2-carboxylic acid as starting compounds. The crude product is purified by chromatography (silica gel and DCM/diethyl ether/methanol=49:49:3) to yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09340522B2
Source datasetuspto-grants-2016_05
ORD IDord-e196d74380454b14b25545884e837d3d
Source noteuspto-grants-2016_05