3-Pyridinecarboxylic acid, 4-(trifluoromethyl)- → HCID 46204652, compound

HRID 524176Notes

Reaction equation

HRID 524176 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].[F:26][C:27]([F:38])([F:37])[C:28]1[C:33]([C:34](O)=[O:35])=[CH:32][N:31]=[CH:30][CH:29]=1>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][N:20]([C:34]([C:33]4[CH:32]=[N:31][CH:30]=[CH:29][C:28]=4[C:27]([F:38])([F:26])[F:37])=[O:35])[CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 27775493-Pyridinecarboxylic acid, 4-(trifluoromethyl)-HCID 666164065-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride2×

Product 1

HCID 46204652HCID 46204652, compound

Procedure

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 4-(trifluoromethyl)nicotinic acid as starting compounds. The crude product is purified by chromatography (silica gel and DCM/diethyl ether/methanol=10:12:1) to yield the title compound.

Workup

  1. customThe title compound is prepared analogously
  2. customThe crude product is purified by chromatography (silica gel and DCM/diethyl ether/methanol=10:12:1)

Sources & evidence

ORD record
ord-57adb607bcb34ba4a7db8b00566d0b60
Source dataset
uspto-grants-2016_05
Patent number
US09340522B2

Reaction notes

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