HRID524180

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2394006

3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid

C12H12F2O4

结构：COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl

HCID66616406

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1ccc(C2=NN(C3CCN(C(=O)c4ccc(OC(F)F)c(OCC5CC5)c4)CC3)C(=O)C2(C)C)cc1OC

HCID46204962

未命名化合物

PROCEDURE

实验过程

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) to yield the title compound.

WORKUP

后处理

customThe title compound is prepared analogously
customThe crude product is purified by chromatography (amino phase silica gel and DCM)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-548ba1cfc2464c05b9dbb4f1cc1f3524
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09340522B2
来源说明: uspto-grants-2016_05

反应 SMILES

Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].[CH:26]1([CH2:29][O:30][C:31]2[CH:32]=[C:33]([CH:37]=[CH:38][C:39]=2[O:40][CH:41]([F:43])[F:42])[C:34](O)=[O:35])[CH2:28][CH2:27]1>>[CH:26]1([CH2:29][O:30][C:31]2[CH:32]=[C:33]([CH:37]=[CH:38][C:39]=2[O:40][CH:41]([F:42])[F:43])[C:34]([N:20]2[CH2:21][CH2:22][CH:17]([N:15]3[C:14](=[O:23])[C:13]([CH3:25])([CH3:24])[C:12]([C:6]4[CH:7]=[CH:8][C:9]([O:10][CH3:11])=[C:4]([O:3][CH3:2])[CH:5]=4)=[N:16]3)[CH2:18][CH2:19]2)=[O:35])[CH2:28][CH2:27]1