HRID524184

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2762479

2-(Morpholin-4-yl)pyridine-4-carboxylic acid

C10H12N2O3

结构：COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl

HCID66616406

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1ccc(C2=NN(C3CCN(C(=O)c4ccnc(N5CCOCC5)c4)CC3)C(=O)C2(C)C)cc1OC

HCID46204966

未命名化合物

PROCEDURE

实验过程

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 2-morpholin-4-ylisonicotinic acid as starting compounds. The crude product is purified by chromatography (silica gel and DCM/methanol=95:5) to yield the title compound.

WORKUP

后处理

customThe title compound is prepared analogously
customThe crude product is purified by chromatography (silica gel and DCM/methanol=95:5)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-43a54989f460473a95f74f66986c3310
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09340522B2
来源说明: uspto-grants-2016_05

反应 SMILES

Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].[N:26]1([C:32]2[CH:33]=[C:34]([CH:38]=[CH:39][N:40]=2)[C:35](O)=[O:36])[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][N:20]([C:35](=[O:36])[C:34]4[CH:38]=[CH:39][N:40]=[C:32]([N:26]5[CH2:27][CH2:28][O:29][CH2:30][CH2:31]5)[CH:33]=4)[CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]