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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 524185Generated: October 30, 2026

Isoquinoline-5-carboxylic acid → HCID 46205294, compound

https://huagongshe.com/reaction/524185

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIsoquinoline-5-carboxylic acidHCID 260936—
Reactant5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochlorideHCID 66616406—
ProductHCID 46205294HCID 46205294—

Reaction Steps

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and isoquinoline-5-carboxylic acid as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from DCM and diethyl ether to yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09340522B2
Source datasetuspto-grants-2016_05
ORD IDord-cf655e6e9fe14261964fdb15efc2d9a5
Source noteuspto-grants-2016_05