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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 524190Generated: October 31, 2026

1H-Indole-5-Carboxylic Acid → HCID 46205620, compound

https://huagongshe.com/reaction/524190

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-Indole-5-Carboxylic AcidHCID 74280—
Reactant5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochlorideHCID 66616406—
ProductHCID 46205620HCID 46205620—

Reaction Steps

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 1H-indole-5-carboxylic acid as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from DCM and diethyl ether to yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09340522B2
Source datasetuspto-grants-2016_05
ORD IDord-55efe8e100244befa1de0dee92710472
Source noteuspto-grants-2016_05