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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 524191Generated: October 29, 2026

1H-indole-6-carboxylic acid → HCID 46205621, compound

https://huagongshe.com/reaction/524191

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-indole-6-carboxylic acidHCID 595230—
Reactant5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochlorideHCID 66616406—
ProductHCID 46205621HCID 46205621—

Reaction Steps

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 1H-indole-6-carboxylic acid as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from DCM and diethyl ether to yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09340522B2
Source datasetuspto-grants-2016_05
ORD IDord-2d953f894a6943f180547877770c33cf
Source noteuspto-grants-2016_05