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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 524192Generated: October 30, 2026

Indole-4-carboxylic acid → HCID 46205622, compound

https://huagongshe.com/reaction/524192

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIndole-4-carboxylic acidHCID 595229—
Reactant5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochlorideHCID 66616406—
ProductHCID 46205622HCID 46205622—

Reaction Steps

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 1H-indole-4-carboxylic acid as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from DCM and diethyl ether to yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09340522B2
Source datasetuspto-grants-2016_05
ORD IDord-d0b82bbe12304d27bac390a80f9fce89
Source noteuspto-grants-2016_05