HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole-2-carboxylic acid → HCID 46205624, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole-2-carboxylic acid | HCID 72899 | — |
| Reactant | 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616406 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 46205624 | HCID 46205624 | — |
Reaction Steps
The title compound is prepared analogously as described for GP2-WU1 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 1H-indole-2-carboxylic acid as starting compounds. The crude product is treated with DMF, the solids are removed by filtration, and the solvent is removed under reduces pressure. The resulting solid is purified by crystallization from DCM and diethyl ether to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340522B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-bae955d8690a43ffa523896878b655b3 |
| Source note | uspto-grants-2016_05 |