HRID524240

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734595

3-methylbenzenesulfonyl Chloride

C7H7ClO2S

结构：COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)c2c1OC1(CCCC1)C2.Cl

HCID66616432

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1ccc(C2=NN(C3CCN(S(=O)(=O)c4cccc(C)c4)CC3)C(=O)C2(C)C)c2c1OC1(CCCC1)C2

HCID67377760

未命名化合物

PROCEDURE

实验过程

The title compound is prepared analogously as described for GP1 using 5-(7-methoxy-3H-spiro[1-benzofuran-2,1′-cyclopentan]-4-yl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B6*HCl) and 3-methylbenzenesulfonyl chloride as starting compounds. The crude product is purified by crystallization from methanol to yield the title compound.

WORKUP

后处理

customThe title compound is prepared analogously
customThe crude product is purified by crystallization from methanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-768fad1a20594caf8edd9982850a2f6f
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09340522B2
来源说明: uspto-grants-2016_05

反应 SMILES

Cl.[CH3:2][O:3][C:4]1[C:16]2[O:15][C:10]3([CH2:14][CH2:13][CH2:12][CH2:11]3)[CH2:9][C:8]=2[C:7]([C:17]2[C:18]([CH3:30])([CH3:29])[C:19](=[O:28])[N:20]([CH:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)[N:21]=2)=[CH:6][CH:5]=1.[CH3:31][C:32]1[CH:33]=[C:34]([S:38](Cl)(=[O:40])=[O:39])[CH:35]=[CH:36][CH:37]=1>>[CH3:2][O:3][C:4]1[C:16]2[O:15][C:10]3([CH2:11][CH2:12][CH2:13][CH2:14]3)[CH2:9][C:8]=2[C:7]([C:17]2[C:18]([CH3:30])([CH3:29])[C:19](=[O:28])[N:20]([CH:22]3[CH2:27][CH2:26][N:25]([S:38]([C:34]4[CH:35]=[CH:36][CH:37]=[C:32]([CH3:31])[CH:33]=4)(=[O:40])=[O:39])[CH2:24][CH2:23]3)[N:21]=2)=[CH:6][CH:5]=1